J. Yuan

Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

This study shows that chemoreceptor clusters and flagellar motors colocalize at the same pole in Pseudomonas aeruginosa, controlled by FlhF, and that CheY overexpression increases c-di-GMP, causing cell aggregation.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Cell Type Specific Responses of the Endoplasmic Reticulum Dynamics to Environmental Stress

This study develops a super-resolution imaging and analysis method to study ER dynamics in Arabidopsis under environmental stress, revealing correlations between ER structure parameters and growth features.

Melatonin serves as a novel treatment in cystic fibrosis and inhibits cystic fibrosis through TGF-β1/Smad and EMT

This study shows melatonin reduces bladder fibrosis by inhibiting the TGF-β1/Smad pathway and epithelial-mesenchymal transition (EMT) in both in vitro and in vivo models.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

CryoSTAR: Leveraging Structural Prior and Constraints for Cryo-EM Heterogeneous Reconstruction

CryoSTAR uses atomic models as constraints to improve cryo-EM reconstruction of conformational heterogeneity, showing better results across multiple datasets.

An axonemal intron splicing program sustains Plasmodium male development

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.

Entropic interfacial charge separation suppresses coarsening of nanoscale condensates

The paper identifies an entropic charge separation mechanism that limits coarsening in nanoscale condensates, explaining their long-term stability.

The inhibitory mechanism of a small protein reveals its role in antimicrobial peptide sensing

This study reveals how the small protein MgrB inhibits the sensor kinase PhoQ, modulating bacterial virulence and antimicrobial peptide sensing.

Potassium-mediated bacterial chemotactic response

This study investigates how Escherichia coli uses potassium concentration changes for chemotaxis, revealing distinct responses from two chemoreceptors and linking potassium sensing to intracellular pH changes.

Systems engineering of Saccharomyces cerevisiae for synthesis and accumulation of vanillin

This paper engineers Saccharomyces cerevisiae to produce vanillin from glucose, achieving the highest reported titer through genetic modifications and metabolic optimization.

Phytochrome higher order mutants reveal a complex set of light responses in the moss Physcomitrium patens

The paper investigates the light response mechanisms in mosses by analyzing phytochrome mutants, finding distinct roles for different phytochrome clades in sensing red and far-red light.

EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

eEF2 improves dense connective tissue repair and healing outcome by regulating cellular death, autophagy, apoptosis, proliferation and migration

The paper identifies eEF2 as a prognostic biomarker for dense connective tissue repair outcomes and shows it regulates cellular processes to improve healing.

Germline determinants of the prostate tumor genome

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

Enhanced protein synthesis is a defining requirement for neonatal B cell development

This study identifies elevated protein synthesis as a critical requirement for neonatal B cell development, regulated by LIN28B and dependent on IL-7 signaling.

Differential bending stiffness of the bacterial flagellar hook under counterclockwise and clockwise rotations

The paper measures the bending stiffness of the bacterial flagellar hook under counterclockwise and clockwise rotations, finding it doubles under clockwise rotation.

Molecular and genetic mechanisms conferring dissolution of dioecy in Diospyros oleifera Cheng

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

Massively-parallel Microbial mRNA Sequencing (M3-Seq) reveals heterogenous behaviors in bacteria at single-cell resolution

The paper introduces M3-Seq, a single-cell RNA-sequencing platform for bacteria, and demonstrates its ability to reveal rare populations and stress response strategies.

Spatial compartmentalization of signalling imparts source-specific functions on secreted factors

The paper identifies distinct functions of VEGFA from different cell types in skeletal muscle regeneration through time-resolved transcriptomic analysis and functional experiments.

Distinct roles of Nrf1 and Nrf2 in monitoring the reductive stress response to dithiothreitol (DTT)

This paper investigates the distinct roles of Nrf1 and Nrf2 in the reductive stress response to DTT, showing differential regulation of redox and ER stress defense genes.

GWAS identifies candidate genes controlling adventitious rooting in Populus trichocarpa

This study uses GWAS to identify 277 candidate genes associated with adventitious rooting in Populus trichocarpa, highlighting roles in hormone signaling, cell division, and reactive oxygen species.

GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa

This study uses GWAS to identify candidate genes regulating in planta regeneration in Populus trichocarpa, finding over 200 genes involved in cell adhesion, stress signaling, and hormone pathways.

Robust high-throughput phenotyping with deep segmentation enabled by a web-based annotator

This paper introduces a high-throughput plant phenotyping system with a GUI and SGIOS algorithm to streamline training data generation and improve GWAS for trait variation analysis.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

Inner membrane complex proteomics reveals a palmitoylation cascade regulating intraerythrocytic development of malaria parasite

The paper identifies IMC proteins in Plasmodium yoelii and shows DHHC2 palmitoylates CDPK1 and GAP45 for their localization, essential for schizont development.

High-titer production of aromatic amines in metabolically engineered Escherichia coli

This paper reports the high-titer production of aromatic amines in engineered E. coli by optimizing carbon source and deleting fermentation byproduct genes.

High-performance Saccharomyces cerevisiae-based biosensor for heavy metal detection

This paper develops a Saccharomyces cerevisiae-based biosensor for copper ion detection with reduced noise and improved signal output, using colorimetric and olfactory outputs for on-site monitoring.

Direct precise measurement of the stall torque of the flagellar motor in E. coli

This study directly measures the stall torque of E. coli flagellar motors using magnetic tweezers, finding each stator unit passes 2 protons per step.