J. Hwang

MYBL2 drives prostate cancer plasticity and identifies CDK2 as a therapeutic vulnerability in RB1-loss and neuroendocrine prostate cancer

This study identifies MYBL2 as a master regulator of phenotypic plasticity in prostate cancer and shows CDK2 inhibition as a potential therapeutic strategy for MYBL2-driven tumors.

The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet.

This study shows that parasympathetic cholinergic neurons innervating the liver prevent hepatic steatosis in mice on a high-fat diet by promoting browning of white adipose tissue and altering bile acid metabolism.

Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen.

The paper identifies short linear sequences in the ER lumen that function as degrons, enabling proteasomal degradation via the ERAD system in yeast and mammalian cells.

Saracatinib synergizes with enzalutamide to downregulate androgen receptor activity in castration resistant prostate cancer

This study shows that combining saracatinib with enzalutamide reduces androgen receptor activity and DNA replication in CRPC cell lines, leading to increased apoptosis.

Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function

The paper identifies cytosolic regions in Hrd1 critical for lumenal ERAD substrate degradation through deep mutational scanning and functional assays.

SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility

This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

This study identifies ST6GAL1 sialyltransferase as a promoter of acinar-to-ductal metaplasia and pancreatic cancer progression through glycosylation-dependent mechanisms.

Uneven terrain treadmill walking in younger and older adults

This study tests how varying treadmill terrain unevenness affects gait kinematic variability and perceived stability in younger and older adults.

Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma

The paper uses spatial single-cell analysis to show that CD73 and CD39 expression in glioblastoma correlates with poor clinical outcomes and immunosuppressive signaling.

The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

DEET as a feeding deterrent

This study demonstrates that DEET reduces feeding time in mosquitoes when mixed with blood, distinguishing it as a feeding deterrent rather than just a contact repellent.