B. R. Iyengar

De novo ORFs are more likely to shrink than to elongate during neutral evolution.

The paper models ORF evolution as a Markov-jump process and shows that de novo ORFs are more likely to shrink than elongate in neutral evolution, supporting the idea that selection retains longer ORFs.

A direct experimental test of Ohno's hypothesis

This study experimentally tests Ohno's hypothesis by evolving fluorescent protein genes in E. coli, finding that double-copy populations show increased mutational robustness and diversity but not accelerated phenotypic evolution.

How antisense transcripts can evolve to encode novel proteins

This study shows antisense transcript overlap with existing ORFs can increase ORF emergence and reduce ORF loss in specific reading frames.

Neutral models of de novo gene emergence suggest that gene evolution has a preferred trajectory

The paper develops neutral models to study de novo gene emergence, finding genes are lost faster than they emerge and long ORFs preferentially arise in transcribed regions.

GroEL/S helps purge deleterious mutations and reduce genetic diversity during adaptive protein evolution

This study shows that GroE chaperones reduce genetic diversity and purge deleterious mutations during adaptive evolution of GFP in E. coli.