Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in pseudo-aspidosperma alkaloid biosynthesis
M. O. Kamileen, M. DeMars, B. Hong, Y. Nakamura, C. Paetz, B. R. Lichman, P. D. Sonawane, L. Caputi, S. E. O'Connor
The paper shows that redox enzymes can alter the regioselectivity of cycloaddition reactions in alkaloid biosynthesis, enabling the formation of pseudo-aspidosperma alkaloids.
bioRxiv · Sep 13, 2022Biochemistry