Author

L. Caputi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Plant Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:plant (other)· 6 Research Focus:cell type annotation· 5 Assay:metabolomics· 3 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

S. E. O'Connor· 7 shared C. R. Buell· 4 shared C. Li· 3 shared J. C. Wood· 3 shared A. H. Vu· 2 shared B. Hong· 2 shared B. Vaillancourt· 2 shared C. Paetz· 2 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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7 shared papersBiochemistry

S. E. O'Connor

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Author profile →

8 papers

Recent·Most cited

Quantitative single cell mass spectrometry reveals the dynamics of plant natural product biosynthesis

A. H. Vu, M. Kang, J. Wurlitzer, S. Heinicke, C. Li, J. C. Wood, V. Grabe, C. R. Buell, L. Caputi, S. E. O'Connor

The paper develops a method for single cell mass spectrometry to quantify natural products in plant cells, revealing biosynthetic dynamics not captured by scRNA-seq.

bioRxiv · Apr 23, 2024 · PreprintBiochemistry

Cell-type aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus

C. Li, M. Colinas, J. C. Wood, B. Vaillancourt, J. P. Hamilton, S. L. Jones, L. Caputi, S. E. O'Connor, C. R. Buell

The paper constructs a cell-type-aware gene regulatory network for MIA biosynthesis in C. roseus using single-cell multi-omics data, identifying a novel idioblast-specific TF that regulates late-stage biosynthetic genes.

bioRxiv · Apr 23, 2024 · PreprintPlant Biology

Biosynthesis of iridoid sex pheromones in aphids

T. G. Koellner, A. David, K. Luck, F. Beran, G. Kunert, J.-J. Zhou, L. Caputi, S. E. O'Connor

This study identifies the biosynthetic pathway for iridoid sex pheromones in pea aphids, revealing an independently evolved pathway distinct from plants.

bioRxiv · Sep 13, 2022Biochemistry

Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in pseudo-aspidosperma alkaloid biosynthesis

M. O. Kamileen, M. DeMars, B. Hong, Y. Nakamura, C. Paetz, B. R. Lichman, P. D. Sonawane, L. Caputi, S. E. O'Connor

The paper shows that redox enzymes can alter the regioselectivity of cycloaddition reactions in alkaloid biosynthesis, enabling the formation of pseudo-aspidosperma alkaloids.

bioRxiv · Sep 13, 2022Biochemistry

Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism

C. Langley, E. E. Tatsis, B. Hong, Y. Nakamura, C. Paetz, C. E. M. Stevenson, J. Basquin, D. M. Lawson, L. Caputi, S. E. O'Connor

The paper reports the crystal structure of an ADH enzyme that catalyzes a non-canonical 1,4 reduction, providing insights into how plant ADHs diversify their catalytic functions.

bioRxiv · Jul 24, 2022Biochemistry

Single-cell multi-omics enabled discovery of alkaloid biosynthetic pathway genes in the medical plant Catharanthus roseus

C. Li, J. C. Wood, A. H. Vu, J. P. Hamilton, C. E. Rodriguez Lopez, R. M. E. Payne, D. A. Serna Guerrero, K. Yamamoto, B. Vaillancourt, L. Caputi, S. E. O'Connor, C. R. Buell

The paper uses single-cell multi-omics to identify alkaloid biosynthesis genes in Catharanthus roseus, revealing gene clusters, paralogs, and cell-type specific expression patterns.

bioRxiv · Jul 4, 2022 · PreprintPlant Biology

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant

S. E. O'Connor, S. Farrow, O. M. Kamileen, L. Caputi, K. Bussey, J. Mundy, R. McAtee, C. Stephenson

The paper reports the biosynthesis of (-)-voacangine and its conversion to (-)-ibogaine, revealing enantioselectivity in enzymatic Diels-Alder reactions for anti-addiction alkaloids.

bioRxiv · May 26, 2019Biochemistry

Identification of Iridoid Synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry

N. H. Sherden, B. Lichman, L. Caputi, D. Zhao, M. O. Kamileen, C. R. Buell, S. O'Connor

The paper identifies iridoid synthase enzymes in two Nepeta species and shows they do not determine nepetalactone stereochemistry, which is instead established later in the biosynthetic pathway.

bioRxiv · Aug 22, 2017Biochemistry