Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Anti-Fibrotic and Anti-Metastatic Compounds
E. M. Lisabeth, D. Kahl, I. Gopallawa, S. E. Haynes, S. A. Misek, P. L. Campbell, T. S. Dexheimer, D. Khanna, D. A. Fox, X. Jin, B. R. Martin, S. D. Larsen, R. R. Neubig
This study identifies pirin as the molecular target of the CCG-1423/CCG-203971 compounds, showing its role in modulating MRTF-dependent gene expression and fibrosis.
bioRxiv · Oct 31, 2018Pharmacology & Toxicology