Author

S. E. Haynes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. I. Nesvizhskii· 2 shared M. A. Cianfrocco· 2 shared Z. Tan· 2 shared A. C. Drotos· 1 shared A. Kriebel· 1 shared A. L. Solon· 1 shared A. Woloshin· 1 shared B. N. Wolford· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

A. I. Nesvizhskii

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Autoinhibited kinesin-1 adopts a hierarchical folding pattern

Z. Tan, Y. Yue, F. da Veiga Leprevost, S. E. Haynes, V. Basrur, A. I. Nesvizhskii, K. J. Verhey, M. A. Cianfrocco

This study determines the structure of autoinhibited kinesin-1 using XL-MS, EM, and AlphaFold, showing how light chains stabilize the inhibited state and how activation requires disrupting multiple domain interactions.

bioRxiv · Jan 26, 2023Biophysics

Teaching Python for Data Science: Collaborative development of a modular & interactive curriculum

M. Duda, K. L. Sovacool, N. Farzaneh, V. K. Nguyen, S. E. Haynes, H. Falk, K. L. Furman, L. A. Walker, R. Diao, M. Oneka, A. C. Drotos, A. Woloshin, G. A. Dotson, A. Kriebel, L. Meng, , B. N. Wolford

The paper describes the development of an open-source, modular Python data science curriculum for high school women using Jupyter notebooks and collaborative practices.

bioRxiv · Jun 17, 2021Scientific Communication & Education

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding

A. L. Solon, Z. Tan, K. L. Schutt, L. Jepsen, S. E. Haynes, A. I. Nesvizhskii, D. Sept, J. Stumpff, R. Ohi, M. A. Cianfrocco

This study determines the structural mechanism by which KIFBP remodels kinesin motors to block microtubule-binding, revealing a 2-pronged inhibition strategy.

bioRxiv · Jun 2, 2021Cell Biology

Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Anti-Fibrotic and Anti-Metastatic Compounds

E. M. Lisabeth, D. Kahl, I. Gopallawa, S. E. Haynes, S. A. Misek, P. L. Campbell, T. S. Dexheimer, D. Khanna, D. A. Fox, X. Jin, B. R. Martin, S. D. Larsen, R. R. Neubig

This study identifies pirin as the molecular target of the CCG-1423/CCG-203971 compounds, showing its role in modulating MRTF-dependent gene expression and fibrosis.

bioRxiv · Oct 31, 2018Pharmacology & Toxicology