Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies
J. J. Lee, V. Bernard, A. Semaan, M. E. Monberg, J. Huang, B. M. Stephens, D. Lin, B. R. Weston, M. S. Bhutani, C. L. Haymaker, C. Bernatchez, C. M. Taniguchi, A. Maitra, P. A. Guerrero
This study uses scRNA-seq on pancreatic cancer biopsies to characterize tumor-stromal heterogeneity and ligand-receptor interactions, showing its utility over patient-derived organoids for precision oncology.
bioRxiv · Jul 28, 2020Cancer Biology