J. J. Lee

Bacteriophage {Phi}21s receptor-binding protein evolves new functions through destabilizing mutations that generate non-genetic phenotypic heterogeneity

This study shows that bacteriophage Φ21 evolves new host receptor usage through destabilizing mutations that create non-genetic phenotypic heterogeneity in viral particles.

TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis

This study shows TPPB, a new PKC modulator, reduces neuroinflammation and promotes CNS repair in experimental MS by targeting innate immune cells.

Parsing digital or analogue TCR performance through piconewton forces

The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.

Rapid bacteria-phage coevolution drives the emergence of multi-scale networks

This study shows that multiscale ecological networks between Escherichia coli and bacteriophage Φ21 can emerge rapidly in lab coevolution without spatial structure.

A new framework for metabolic connectivity mapping using bolus FDG PET and kinetic modelling

This paper develops a new framework for within-individual metabolic connectivity using dynamic FDG PET and compares it to across-individual MC and functional connectivity.

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype

This study uses deep learning on plasma extracellular vesicle RNA to predict cancer subtypes, monitor treatment effects, and identify gene fusions and neoepitopes without tissue sampling.

Enhanced capillary pumping using open-channel capillary trees with integrated paper pads

This paper demonstrates enhanced capillary pumping by coupling open-channel capillary trees with paper pads, achieving higher flow rates with viscous liquids.

Comparison of bacterial suppression by phage cocktails, dual-receptor generalists, and coevolutionarily trained phages

This study compares the effectiveness of phage cocktails, dual-receptor generalists, and coevolutionarily trained phages in suppressing bacterial growth, finding that trained generalists are more effective.

Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation

The paper introduces a robust beta regression method for dose-response curve estimation and develops a web tool for its implementation.

Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila

The paper investigates the role of the Pink1-Parkin pathway in mitochondrial quality control in Drosophila, finding that it promotes mitochondrial turnover independently of canonical autophagy.

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution.

This study reveals high intratumoral heterogeneity in pancreatic cancer cell lines and highlights issues with reproducibility and validity of preclinical models.

homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA

homeRNA enables self-collection of peripheral blood and stabilization of RNA at home, with high success rates and good RNA quality.

Eosinophil peroxidase induces inflammation in an animal model of dermatitis

This study shows that eosinophil peroxidase (EPX) promotes inflammation and itch in a dermatitis model through two distinct pathways, suggesting potential therapeutic targets.

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies

This study uses scRNA-seq on pancreatic cancer biopsies to characterize tumor-stromal heterogeneity and ligand-receptor interactions, showing its utility over patient-derived organoids for precision oncology.

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis

This study identifies COUP-TFII as a driver of myofibroblast metabolic shift to aerobic glycolysis, promoting fibrosis in multiple organs.

Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2

This study compares the sensitivity of primer-probe sets for detecting SARS-CoV-2 RNA in N and Orf1 genes, identifying the most sensitive sets for each.

Open channel droplet-based microfluidics

The paper develops open channel droplet-based microfluidics systems using capillary flow for droplet manipulation and demonstrates applications in cell culture and microscale reactions.

Evidence of extensive intraspecific noncoding reshuffling in a 169-kb mitochondrial genome of a basidiomycetous fungus

The paper examines mitochondrial genome rearrangements in basidiomycete fungi, finding lineage-specific evolution and chimeric mitotypes due to intron exchange and intergenic sequence reshuffling.

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

The paper investigates the role of PINK1 and parkin in basal mitophagy in Drosophila, finding no significant impact on basal mitophagy despite locomotor defects and dopaminergic neuron loss.

Flexibility to contingency changes distinguishes habitual and goal-directed strategies in humans

This study investigates how humans adapt to contingency changes in decision-making, finding that participants use a hybrid strategy shifting towards goal-directed behavior over time.