Author

C. M. Taniguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Maitra· 3 shared V. Bernard· 3 shared A. M. Delahoussaye· 2 shared A. Semaan· 2 shared B. M. Stephens· 2 shared D. Lin· 2 shared J. Huang· 2 shared J. J. Lee· 2 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

A. Maitra

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Feasibility of Administering Human Pancreatic Cancer Chemotherapy in a Spontaneous Pancreatic Cancer Mouse Model

A. M. Delahoussaye, J. A. Jaoude, T. N. Fujimoto, J. Molkentine, C. J. G. Garcia, J. P. Gay, N. Feng, J. Marszalek, C. M. Taniguchi

This study demonstrates the feasibility of administering clinical chemotherapy regimens, mFOLFIRINOX and gemcitabine/nab-paclitaxel, in a spontaneous pancreatic cancer mouse model, showing improved survival compared to controls.

bioRxiv · Sep 8, 2021Cancer Biology

Comparative untargeted metabolomic profiling of induced mitochondrial fusion in pancreatic cancer

N. D. Nguyen, M. Yu, V. Y. Reddy, A. C. Acevedo-Diaz, E. C. Mesarick, J. Abi Jaoude, M. Yuan, J. M. Asara, C. M. Taniguchi

The paper compares metabolic changes induced by three methods of mitochondrial fusion in pancreatic cancer cells and identifies common amino acid metabolism alterations.

bioRxiv · Aug 6, 2021Cancer Biology

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

Y. Huang, C. J. Garcia Garcia, D. Lin, N. D. Nguyen, T. N. Fujimoto, J. Zhao, J. J. Lee, V. Bernard, M. Yu, A. M. Delahoussaye, J. L. Phan, A. Deorukhkar, J. M. Molkentine, N. R. Fuentes, M. C. Turner, , C. M. Taniguchi

This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.

bioRxiv · May 21, 2021 · PreprintCancer Biology

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies

J. J. Lee, V. Bernard, A. Semaan, M. E. Monberg, J. Huang, B. M. Stephens, D. Lin, B. R. Weston, M. S. Bhutani, C. L. Haymaker, C. Bernatchez, C. M. Taniguchi, A. Maitra, P. A. Guerrero

This study uses scRNA-seq on pancreatic cancer biopsies to characterize tumor-stromal heterogeneity and ligand-receptor interactions, showing its utility over patient-derived organoids for precision oncology.

bioRxiv · Jul 28, 2020Cancer Biology

Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

V. Bernard, A. Semaan, J. Huang, F. A. San Lucas, F. C. Mulu, B. M. Stephens, P. A. Guerrero, Y. Huang, J. Zhao, N. Kamyabi, S. Sen, P. A. Scheet, C. M. Taniguchi, M. P. Kim, C.-W. Tzeng, , H. A. Alvarez

This study uses single-cell RNA sequencing to analyze transcriptomic changes in pancreatic cancer precursors, revealing epithelial and microenvironmental heterogeneity during progression to cancer.

bioRxiv · Apr 26, 2018Pathology