Author

A. Semaan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3 Research Focus:cell-cell communication· 1

Frequent Co-Authors

P. A. Guerrero· 4 shared V. Bernard· 4 shared A. Maitra· 3 shared B. M. Stephens· 3 shared C. M. Taniguchi· 2 shared J. Huang· 2 shared J. J. Lee· 2 shared M. E. Monberg· 2 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

P. A. Guerrero

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Author profile →

4 papers

Recent·Most cited

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project

A. Semaan, V. Bernard, J. Wong, Y. Makino, D. Swartzlander, K. I. Rajapakshe, J. Lee, A. Officer, C. M. Schmidt, H. H. Wu, C. L. Scaife, K. E. Affolter, D. Nachmanson, M. A. Firpo, M. Yip-Schneider, , P. A. Guerrero

This study integrates genomic and transcriptomic analysis of intraductal papillary mucinous neoplasms (IPMNs) to identify molecular features associated with progression to high-grade lesions and cancer.

bioRxiv · Oct 14, 2022 · PreprintCancer Biology

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution.

M. E. Monberg, H. Geiger, R. Sharma, J. J. Lee, A. Semaan, V. Bernard, D. B. Swartzlander, B. M. Stephens, K. Chen, M. H. Katz, N. Robine, P. A. Guerrero, A. Maitra

This study reveals high intratumoral heterogeneity in pancreatic cancer cell lines and highlights issues with reproducibility and validity of preclinical models.

bioRxiv · Apr 13, 2021Cancer Biology

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies

J. J. Lee, V. Bernard, A. Semaan, M. E. Monberg, J. Huang, B. M. Stephens, D. Lin, B. R. Weston, M. S. Bhutani, C. L. Haymaker, C. Bernatchez, C. M. Taniguchi, A. Maitra, P. A. Guerrero

This study uses scRNA-seq on pancreatic cancer biopsies to characterize tumor-stromal heterogeneity and ligand-receptor interactions, showing its utility over patient-derived organoids for precision oncology.

bioRxiv · Jul 28, 2020Cancer Biology

Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

V. Bernard, A. Semaan, J. Huang, F. A. San Lucas, F. C. Mulu, B. M. Stephens, P. A. Guerrero, Y. Huang, J. Zhao, N. Kamyabi, S. Sen, P. A. Scheet, C. M. Taniguchi, M. P. Kim, C.-W. Tzeng, , H. A. Alvarez

This study uses single-cell RNA sequencing to analyze transcriptomic changes in pancreatic cancer precursors, revealing epithelial and microenvironmental heterogeneity during progression to cancer.

bioRxiv · Apr 26, 2018Pathology