Improvements on Sample Preparation and Peptide Separation for Reduced Peptide Mapping Based Multi-Attribute Method analysis of Therapeutic Monoclonal Antibodies Using Lys-C Digestion
X. Li, B. Rawal, S. Rivera, S. Letarte, D. Richardson
This paper improves sample preparation and peptide separation for reduced peptide mapping-based MAM analysis of therapeutic monoclonal antibodies using Lys-C digestion, enhancing PQA monitoring for hydrophilic peptides.
bioRxiv · Feb 28, 2022 · PreprintBiochemistry