Y.-F. Chang

Genomic characterization of Escherichia coli harbor a polyketide synthase (pks) island associated with colorectal cancer (CRC) development

This study characterizes the genomic distribution and evolution of pks islands in E. coli strains associated with colorectal cancer, revealing phylogenetic patterns and horizontal gene transfer.

Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli

This study shows that turgor pressure in E. coli increases with growth rate and directly controls cell wall biosynthesis rate.

Plasticity of growth laws tunes resource allocation strategies in bacteria

This study shows that nutrient quality in bacteria is a plastic property shaped by proteome allocation, not a fixed biochemical constraint, and can be modified through genetic engineering.

Long-term history dependence of growth rates of E. coli after nutrient shifts

This study shows that E. coli growth rates on carbon source combinations depend on prior growth conditions, persisting for 15 generations and involving the transcription factor Mlc.

The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies

This paper develops a method to efficiently generate human retinal ganglion-like cells from iPSCs and uses them to study the effects of ethambutol on RGC degeneration.

Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using qCART, the Quantum pBac-based CAR-T system

This paper demonstrates the efficient manufacturing of CD20/CD19 dual-targeted, iCasp9-regulatable CAR-TSCM cells using the virus-free qCART system, showing robust tumor eradication and safety.

The energy requirements of ion homeostasis determine the lifespan of starving bacteria

This study identifies ion homeostasis as a key determinant of bacterial lifespan during starvation, showing that reducing its energetic cost extends survival.

Plakoglobin and HMGB1 mediate intestinal epithelial cell apoptosis induced by Clostridioides difficile TcdB

This study identifies plakoglobin and HMGB1 as key mediators of TcdB-induced intestinal epithelial cell apoptosis through mitochondrial pathways.

MetA is a thermal fuse that arrests growth and protects Escherichia coli at elevated temperatures

The paper shows that E. coli uses MetA degradation to induce growth arrest and enhance survival at high temperatures.

Scavenger receptor A1 participates in the phagocytosis of Leptospira interrogans and leads to subsequent high inflammatory responses and bacterial dissemination in leptospirosis

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

Leptospira surface protein LigA plays a multifaceted role in modulating the host innate immune response

This study identifies the LigA surface protein's A11 domain as a key factor in Leptospira's ability to modulate host immune responses and evade complement-mediated killing.

A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein

The paper develops and validates a new red fluorescent calcium indicator, K-GECO1, based on a circularly permutated RFP from a sea anemone, tested across multiple cell types and organisms.