B. S. Marteyn

SPATEs promote the survival of Shigella to the plasma complement system upon hemorrhage and bacteremia

This study shows Shigella survives plasma exposure via SPATEs, which cleave C3 to impair complement activation, enhancing virulence during bacteremia.

Neutrophils degranulate GAG-containing proteoglycofili, which block Shigella growth and degrade virulence factors

This study shows that neutrophil degranulation releases PGF, which inhibit Shigella growth and degrade its virulence factors, and that hyaluronidase treatment disrupts PGF structure and antimicrobial activity.

Preventing neutrophil from oxygen exposure allows their basal state maintenance

This study shows that oxygen exposure during neutrophil purification and culture leads to activation and loss of cytosolic proteins, and recommends maintaining them in anoxic conditions to preserve their basal state.

The ascorbate-deficient guinea pig model of shigellosis allows the study of the entire Shigella life cycle

This paper develops an ascorbate-deficient guinea pig model to study the full Shigella life cycle and immune responses, showing increased infection severity and prolonged bacterial dissemination.

IlvY is an important regulator of Shigella infection in vitro and in vivo

This paper identifies IlvY as a critical regulator of Shigella virulence in vitro and in vivo using a novel oral mouse model.

Ascorbate maintains a low plasma low oxygen level

The paper quantifies human plasma oxygen levels and identifies ascorbate-dependent oxygen-reduction activity, showing its role in preserving oxidation-sensitive components and influencing leucocyte biology.