J.-Y. Tinevez

MiniBAR/KIAA0355 is a dual Rac and Rab effector required for ciliogenesis

This study identifies MiniBAR as a dual Rac and Rab effector essential for ciliogenesis, showing its role in coordinating actin dynamics and membrane trafficking.

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

The paper develops a microfluidic platform to screen compounds that reduce bacterial phenotypic variation and enhance tuberculosis drug efficacy.

Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysis

This study characterizes beta-cell adaptation to insulin resistance in mice, showing that neogenesis is a key mechanism, persists with aging, and is confirmed by a new 3D analysis method.

ExTrack characterizes transition kinetics and diffusion in noisy single-particle tracks

ExTrack analyzes noisy single-particle tracks to characterize transition kinetics and diffusion by using probabilistic modeling of spatio-temporal data.

Neutrophils degranulate GAG-containing proteoglycofili, which block Shigella growth and degrade virulence factors

This study shows that neutrophil degranulation releases PGF, which inhibit Shigella growth and degrade its virulence factors, and that hyaluronidase treatment disrupts PGF structure and antimicrobial activity.

Molecular organization and mechanics of single vimentin filaments revealed by super-resolution imaging

This study uses super-resolution imaging to show vimentin filaments have a 49 nm axial repeat, with subunit unfolding contributing to their extensibility.

Concentration of intraflagellar transport proteins at the ciliary base is required for proper train injection

The paper shows that concentrating IFT proteins at the flagellum base is necessary for proper IFT train injection in Trypanosoma brucei.

HIV-induced membraneless organelles orchestrate post-nuclear entry steps.

This study identifies HIV-induced membraneless organelles that facilitate viral replication by reorganizing the nuclear environment and promoting reverse transcription.

Automated cell tracking using StarDist and TrackMate

This paper presents an automated cell tracking pipeline using StarDist and TrackMate for 2D live-cell imaging, applicable to fluorescent and brightfield images without coding knowledge.

Imaging of red-shifted photons from bioluminescent tumours using fluorescence by unbound excitation from luminescence

The paper applies FUEL to enhance bioluminescence imaging for deeper tumour detection in two models.

Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum

This study identifies two distinct IFT tracks in trypanosome flagella using microscopy, showing bidirectional transport on parallel lines and dynamic conversion of anterograde to retrograde trains.