An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment
D. YANG, J. Li, T. Zhang, Q. Shi, G. Lv, X. Zhou, N. CHOUDHRY, J. Kalashova, C. Yang, H. Li, Y. Long, B. Sakthivel, N. Nimishetti, H. Liu, T. D. Allen, J. Zhang
This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.
bioRxiv · Jan 29, 2023 · PreprintCancer Biology