Q. Shi

Promotion of RNF168-Mediated Nucleosomal H2A Ubiquitylation by Structurally-defined K63-Polyubiquitylated Linker Histone H1

This study develops a chemical synthesis method to create polyubiquitylated linker histone H1.0, revealing its role in enhancing RNF168-mediated H2A ubiquitylation through structural and biochemical analysis.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

Pharmacokinetics, Tissue Distribution, and Formulation Study of a Small-molecule Inhibitor of MKLP2, LG157

This study evaluates the drug developability of LG157, a MKLP2 inhibitor, by assessing its pharmacokinetics, tissue distribution, and formulation using SEDDS.

ARBUR, a machine learning-based analysis system for relating behaviors and ultrasonic vocalizations of rats

ARBUR is a machine learning system that clusters rat ultrasonic vocalizations and detects social behaviors, revealing communication patterns and novel findings in social interactions.

MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality

This study shows that LXY18 selectively kills MYC-overexpressing cancer cells by inducing mitotic arrest, offering a new approach to target MYC-driven tumors.

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

The role of neutrophil typing in homeostatic resilience protective model of inflammatory preconditioning

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.

Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming

This study identifies how Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis promote oncogenic changes in colorectal cancer by affecting epithelial cells and immune responses.

Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

Frizzled-9 activates YAP to rescue simulated microgravity induced osteoblasts dysfunction.

This study shows that Fzd9 overexpression rescues SMG-induced osteoblast dysfunction by activating YAP through actin polymerization and nuclear translocation.

An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control

This study shows that inhibiting MAO-A in cardiomyocytes reduces arrhythmias by improving diastolic calcium control following catecholamine stress.

Inflammatory bowel disease-associated gut commensals degrade components of the extracellular matrix

This study shows gut commensals degrade extracellular matrix components in vitro and links this activity to IBD progression through proteolytic and enzymatic mechanisms.

Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

This study uses a transgenic mouse model to show that sustained HOTAIR expression promotes breast cancer metastasis and that its removal reverses metastatic traits, indicating an erasable epigenetic memory.

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.

Ultra-high-throughput microbial single-cell whole genome sequencing for genome-resolved metagenomics

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Two Liberibacter Effectors Combine to Suppress Critical Innate Immune Defenses and Facilitate Huanglongbing Pathogenesis in Citrus

The paper investigates two CLas effectors, P235 and Effector 3, showing they suppress citrus innate immune responses and contribute to HLB pathogenesis by inhibiting immune proteins and inducing cell death.

A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity

Drought stress delays photosynthetic induction and accelerates photoinhibition of photosystem I under fluctuating light

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

Deterministic shifts in molecular evolution correlate with convergence to annualism in killifishes

The paper shows that annual life history in killifishes is linked to higher evolutionary rates in genes involved in development and metabolism.

The tetrameric assembly of 2-aminomuconic acid dehydrogenase is a functional requirement of cofactor NAD+ binding

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers

Ultrasound-mediated blood-brain barrier disruption improves anti-pyroglutamate3 Aβ antibody efficacy and enhances phagocyte infiltration into brain in aged Alzheimer's disease-like mice

This paper shows that combining ultrasound with an antibody improves Aβ removal and memory in Alzheimer's mice without causing brain bleeding.

EcDNA hubs drive cooperative intermolecular oncogene expression

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

Characterization of LC-MS based urine metabolomics in healthy subjects across the life span

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

A multifaceted cellular damage repair and prevention pathway promotes high level tolerance to β-lactam antibiotics

This study shows that the VxrAB system in Vibrio cholerae reduces β-lactam antibiotic toxicity by managing iron levels and oxidative damage, enhancing bacterial tolerance.