B. Seddon

A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice

This study maps the ontogeny of Treg subsets in mice, showing naive and effector/memory Treg are continuously replenished by de novo generation, with naive Treg being the main precursor of EM Treg in adults.

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

This study shows that memory CD4+ T cell persistence depends on cell age, not host chronological age, using mouse models and mathematical models.

NF-κB dependent expression of A20 controls IKK repression of RIPK1 dependent cell death in activated T cells

This study shows that IKK signaling in T cells protects against RIPK1-dependent cell death by phosphorylating RIPK1 and inducing A20, which modulates RIPK1 function.

Towards a unified model of naive T cell dynamics across the lifespan

This study develops a unified model of naive CD4 and CD8 T cell dynamics across the mouse lifespan, revealing that survival capacity increases with age and that naive CD8 T cells are rapidly lost early in life.

Tonic IKK signalling regulates naive T cell survival in vivo by both repressing RIPK1 dependent extrinsic cell death pathways and independent activation of NF-κB

Fate mapping quantifies the dynamics of B cell development and activation throughout life

This study uses fate mapping in mice to show differences in B cell dynamics between follicular and germinal center cells across life.

Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

This study investigates how self and environmental antigens influence the development and maintenance of CD4+ T cell memory in mice, showing early environmental exposure shapes memory populations, while later replenishment is environment-independent.