S. Barry

A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice

This study maps the ontogeny of Treg subsets in mice, showing naive and effector/memory Treg are continuously replenished by de novo generation, with naive Treg being the main precursor of EM Treg in adults.

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

This study develops a second-generation AKT degrader, INY-05-040, showing improved efficacy over existing inhibitors in breast cancer cells by inducing stress MAPK signaling.

Predicting catchment suitability for biodiversity at national scales

This paper links water quality and land use data to predict catchment suitability for threatened and invasive freshwater species, showing how management actions can be prioritized for biodiversity conservation.

A novel method accounting for predictor uncertainty and model transferability of invasive species distribution models

This paper introduces a method using multiple simple models to improve model transferability and account for predictor uncertainty in invasive species distribution models.

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation

This study identifies three distinct effector pathways regulated by Apc in murine intestinal epithelia, each contributing to normal tissue homeostasis and tumorigenesis when disrupted by oncogenic Apc mutations.

Targeting DNA damage response and Replication Stress in Pancreatic Cancer

The paper identifies novel therapeutic strategies for pancreatic cancer by analyzing DNA damage response and replication stress in patient-derived cell lines.