A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss
K. S. Chichura, C. T. Elfers, T. Salameh, V. Kamat, O. G. Chepurny, A. McGivney, B. T. Milliken, G. G. Holz, S. V. Appleby, M. R. Hayes, I. R. Sweet, C. L. Roth, R. P. Doyle
The paper shows that peptide agonists of GLP-1, Y1-R, and Y2-R improve glycemic control and weight loss in rats, with Y1-R antagonism enhancing GLP-1R effects.
bioRxiv · Nov 7, 2022Pharmacology & Toxicology