Author

V. Kamat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

I. R. Sweet· 4 shared A. Brousseau· 1 shared A. Dehkharghani· 1 shared A. J. Murphy· 1 shared A. McGivney· 1 shared A. N. Economides· 1 shared A.-L. B. G. Vigil· 1 shared B. G. K. Perera· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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4 shared papersCancer Biology

I. R. Sweet

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Author profile →

6 papers

Recent·Most cited

Alpaca Single B Cell Interrogation and Heavy-Chain-Only Antibody Discovery on an Optofluidic Platform

M. B. Shapiro, J. Boucher, A. Brousseau, A. Dehkharghani, J. Gabriel, V. Kamat, K. Patil, F. Gao, J. Walker, R. Kelly, C. A. Souders

This paper develops a method to discover heavy-chain-only antibodies from alpaca B cells using an optofluidic platform and validates PSMA-specific VHH candidates.

Antibody Therapeutics · Aug 17, 2023Peer-reviewedImmunology

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

T. Uo, K. K. Ojo, C. C. Sprenger, K. S. Epilepsia, B. G. K. Perera, M. Damodarasamy, S. Sun, S. Kim, H. H. Hogan, M. A. Hulverson, R. Choi, G. R. Whitman, L. K. Barrett, S. A. Michaels, L. H. Xu, , S. R. Plymate

This paper evaluates a novel antiglycolytic compound, BKIDC-1553, showing selective growth inhibition of prostate cancer cells and safety for clinical trials.

bioRxiv · Jul 1, 2023Cancer Biology

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)

G. Pharaoh, V. Kamat, S. Kannan, R. S. Stuppard, J. Whitson, M. Martin-Perez, W.-J. Qian, M. J. MacCoss, J. Villen, P. Rabinovitch, M. D. Campbell, I. R. Sweet, D. J. Marcinek

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

bioRxiv · Feb 1, 2023 · PreprintPhysiology

A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss

K. S. Chichura, C. T. Elfers, T. Salameh, V. Kamat, O. G. Chepurny, A. McGivney, B. T. Milliken, G. G. Holz, S. V. Appleby, M. R. Hayes, I. R. Sweet, C. L. Roth, R. P. Doyle

The paper shows that peptide agonists of GLP-1, Y1-R, and Y2-R improve glycemic control and weight loss in rats, with Y1-R antagonism enhancing GLP-1R effects.

bioRxiv · Nov 7, 2022Pharmacology & Toxicology

ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

S. Aykul, L. Huang, L. Wang, N. Das, S. Reisman, Y. Ray, Q. Zhang, N. Rothman, K. C. Nannuru, V. Kamat, S. Brydges, L. Troncone, L. Johnsen, P. B. Yu, S. Fazio, , S. J. Hatsell

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.

bioRxiv · Jul 18, 2021Biochemistry

Fluidics System for Resolving Concentration-Dependent Effects of Dissolved Gases on Tissue Metabolism

I. R. Sweet, J. B. Hurley, V. Kamat, B. M. Robbings, K. P. Bube, S.-R. Jung, J. Kelly

This paper introduces a fluidics system to study how dissolved gases affect tissue metabolism and function, revealing new insights into oxygen consumption and hydrogen sulfide effects on insulin secretion.

bioRxiv · Mar 7, 2021Cell Biology