The polyploid state plays a tumor suppressive role in the liver
S. Zhang, K. Zhou, X. Luo, L. Li, L. Nguyen, Y. Zhang, B. Tarlow, D. Siegwart, H. Zhu
This study shows that polyploidy in the liver suppresses tumorigenesis while hyperdiploidy accelerates it in mutagen and high fat models.
bioRxiv · Jun 13, 2017Cancer Biology