L. Nguyen

GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

Engineering the microstructure and spatial bioactivity of MAP scaffolds in vitro instructs neovascularization in vivo

This study tunes microstructure and bioactivity of MAP scaffolds to guide cell patterning and promote vessel formation in vitro and enhance neovascularization in vivo.

Structure-function analysis of a calcium-independent metacaspase reveals a novel proteolytic pathway for lateral root emergence

This study solves the structure of a calcium-independent metacaspase and identifies inhibitors that block lateral root emergence in Arabidopsis.

JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis

This study shows JNK signaling supports self-renewal of urine-derived renal progenitor cells by preventing ferroptosis, suggesting its role in kidney disease modeling.

A Closed-Form Adaptation of the Hodgkin-Huxley Membrane Potential and its Synthesis to a Novel Electric Circuit.

This paper presents a closed-form adaptation of the Hodgkin-Huxley model and synthesizes a novel analog circuit simulating action potential dynamics.

Mechanistic insights of glucosome condensate formation by stochastic modeling approaches

This study uses stochastic modeling to investigate how PFKL's biological properties drive glucosome condensate formation in human cells.

TE invasion fuels molecular adaptation in laboratory populations of Drosophila melanogaster

This study shows that transposable element invasion in Drosophila melanogaster leads to molecular adaptation through recurrent insertions into a specific lncRNA under positive selection.

Potent Neutralizing Activity of Polyclonal Equine Antibodies against Omicron SARS-CoV-2

This study demonstrates that equine polyclonal F(ab)2 antibodies achieve high neutralizing potency against SARS-CoV-2 variants, including Omicron, with titers up to 111,403 IU/mL.

Short-Term Dairy Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose Intolerant Adults

This study examines the impact of short-term dairy elimination and reintroduction on gut microbiota and lactose tolerance in self-reported lactose intolerant adults, finding minimal microbiota changes and improved symptom tolerance.

Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Pancreatic Islets

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

Fitness cost associated with enhanced EPSPS gene copy number and glyphosate resistance in an Amaranthus tuberculatus population

The paper assesses the fitness costs of glyphosate resistance in Amaranthus tuberculatus by linking EPSPS gene copy number to growth and competitive ability under different competition conditions.

Arabidopsis Casein Kinase 2 triggers Stem Cell Exhaustion under Al Toxicity and Phosphate Deficiency Through activation of the DNA Damage Response pathway

The paper identifies CK2 and DNA damage response regulators as key factors in controlling Arabidopsis root growth under Al toxicity and phosphate limitation.

Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3

This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

This study compares transmissibility and pathogenicity of recent African and Asian Zika virus strains, finding African strains more transmissible, lethal, and capable of causing fetal death.

Adolescent Alcohol Binge-Drinking induces delayed appearance of behavioral defects in mice

This study shows that adolescent alcohol binge-drinking in mice leads to delayed behavioral impairments in adulthood without immediate effects.

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injury

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.

ATP-Citrate lyase fuels axonal transport across species

The paper identifies ATP-citrate lyase (Acly) as a rate-limiting enzyme modulating Atat1 activity and α-tubulin acetylation, linking Elongator to axonal transport in projection neurons across species.

Asparagine hydroxylation is likely to be a reversible post-translational modification

The paper shows that asparagine hydroxylation can be reversed by cellular machinery, challenging the view that it is irreversible.

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation.

The paper shows that Nix-induced mitochondrial fission, mitophagy, and insulin resistance in myocytes are reversed by PKA phosphorylation.

Pan-cancer landscape of homologous recombination deficiency

This study develops a pan-cancer Classifier of Homologous Recombination Deficiency (CHORD) and identifies HRD frequency and genetic causes across multiple cancer types.

Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks

The paper develops a spatial analytics platform to predict colorectal cancer recurrence and infer tumor microenvironment networks from spatial data.

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.

Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from south and southeast Asia.

This study identifies diverse antimicrobial resistant and hypervirulent Klebsiella pneumoniae strains in South and Southeast Asia, highlighting the convergence of AMR and virulence genes.

Coarse-grained simulations of actomyosin rings point to a nodeless model involving both unipolar and bipolar myosins

The paper uses 3D coarse-grained simulations to test actomyosin ring models, finding that a nodeless arrangement with unipolar and bipolar myosins better matches experimental data than node-based models.

The polyploid state plays a tumor suppressive role in the liver

This study shows that polyploidy in the liver suppresses tumorigenesis while hyperdiploidy accelerates it in mutagen and high fat models.