Inhibition of Replication Origins and ATR Synergistically Activates the Innate Immune System in Cancer Cells
K. Doberstein, J. Panther, S. Berlit, B. Tuschy, M. Suetterlin, F. Marme
The paper shows that inhibiting replication origins and ATR together increases genomic instability and innate immune activation in ovarian cancer cells, but not in normal cells.
Heliyon · Mar 1, 2026Peer-reviewedCancer Biology