Targeting hypoxic habitats with hypoxia pro-drug evofosfamide in preclinical models of sarcoma
B. V. Jardim Perassi, W. Mu, S. Huang, M. R. Tomaszewski, J. Poleszczuk, M. A. Abdalah, M. M. Budzevich, W. Dominguez-Viqueira, D. R. Reed, M. M. Bui, J. O. Johnson, G. V. Martinez, R. J. Gillies
This paper develops deep-learning models to identify hypoxic tumor regions using MRI and histology, showing their effectiveness in predicting hypoxia and guiding TH-302 therapy response in sarcoma models.
bioRxiv · Oct 6, 2020 · PreprintCancer Biology