Author

W. Dominguez-Viqueira

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

R. J. Gillies· 2 shared A. El-Kenawi· 1 shared A. Keske· 1 shared B. Ruffell· 1 shared B. V. Jardim Perassi· 1 shared D. R. Reed· 1 shared G. V. Martinez· 1 shared J. Dhillon· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

R. J. Gillies

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2 papers

Recent·Most cited

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

A. El-Kenawi, W. Dominguez-Viqueira, M. Liu, S. Awasthi, A. Keske, K. K. Steiner, L. Noel, J. Dhillon, R. J. Gillies, K. Yamoah, X. Yu, J. Koomen, R. A. Gatenby, B. Ruffell

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

bioRxiv · Mar 24, 2021Cancer Biology

Targeting hypoxic habitats with hypoxia pro-drug evofosfamide in preclinical models of sarcoma

B. V. Jardim Perassi, W. Mu, S. Huang, M. R. Tomaszewski, J. Poleszczuk, M. A. Abdalah, M. M. Budzevich, W. Dominguez-Viqueira, D. R. Reed, M. M. Bui, J. O. Johnson, G. V. Martinez, R. J. Gillies

This paper develops deep-learning models to identify hypoxic tumor regions using MRI and histology, showing their effectiveness in predicting hypoxia and guiding TH-302 therapy response in sarcoma models.

bioRxiv · Oct 6, 2020 · PreprintCancer Biology