R. J. Gillies

L-DOS47 enhances response to immunotherapy in pancreatic cancer tumor

This study shows that L-DOS47, a urease immunoconjugate, enhances anti-PD1 immunotherapy efficacy in pancreatic cancer by neutralizing tumor acidity.

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

Cycling hypoxia selects for constitutive HIF stabilization

The paper develops a mathematical model showing that rapid oxygen fluctuations favor pseudohypoxia by selecting for constitutive HIF stabilization despite reduced cell fitness.

Targeting hypoxic habitats with hypoxia pro-drug evofosfamide in preclinical models of sarcoma

This paper develops deep-learning models to identify hypoxic tumor regions using MRI and histology, showing their effectiveness in predicting hypoxia and guiding TH-302 therapy response in sarcoma models.

T2 heterogeneity provides a sensitive measure of early tumor response to radiotherapy

This paper introduces a T2 MRI-based biomarker to assess early tumor response to radiotherapy in pancreatic cancer models, showing high sensitivity and robustness.

The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines

This study shows that competition between two breast cancer cell lines depends on frequency-dependent interactions, not just growth rates or carrying capacities.

Mix & Match: Phenotypic coexistence as a key facilitator of solid tumour invasion

This study uses a mathematical model to show that stable coexistence of different cancer cell phenotypes enhances tumour invasion by allowing complementary traits to work synergistically.

Collagen Production and Niche Engineering: A Novel Strategy for Cancer Cells to Survive Acidosis and Evolve

The paper identifies collagen production as an adaptation strategy in acidotic cancer cells, showing correlation with patient survival.