Mechanism of DNA surface exploration and operator bypassing during target search
E. Marklund, B. van Oosten, G. Mao, E. Amselem, K. Kipper, A. Sabantsev, A. Emmerich, D. Globisch, X. Zhen, L. Lehmann, O. Berg, M. Johansson, J. Elf, S. Deindl
This study uses SMCT-FCS to show LacI slides on DNA, bypassing target sequences by hopping out of the DNA groove, revealing a speed-accuracy trade-off in target search.
bioRxiv · Jan 29, 2020Biophysics