Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates
M. G. Pauthner, J. P. Nkolola, C. Havenar-Daughton, B. Murrell, S. M. Reiss, R. Bastidas, J. Prevost, R. Nedellec, B. von Bredow, P. Abbink, C. A. Cottrell, D. W. Kulp, T. Tokatlian, B. Nogal, M. Bianchi, , D. R. Burton
This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.
bioRxiv · Oct 29, 2018Immunology