D. J. Irvine

Glycan-costumed virus-like particles promote type 1 anti-tumor immunity

This study develops glycan-costumed virus-like particles that activate dendritic cells and induce type 1 anti-tumor immunity in a murine model.

Local delivery of cell surface-targeted immunocytokines programs systemic anti-tumor immunity

This study develops CD45-targeted immunocytokines that localize to immune cells in tumors and lymph nodes, eradicating both treated and distant tumors in mouse models.

Two-dose "extended priming" immunization amplifies humoral immune responses by synchronizing vaccine delivery with the germinal center response

This study shows that a two-dose extended priming vaccine regimen enhances humoral immune responses by synchronizing antigen delivery with germinal center dynamics.

WASP facilitates tumor mechanosensitivity in T lymphocytes

This study identifies WASP as a key mediator of mechanosensitivity in CTLs, linking mechanical cues from target cells to TCR signaling and immune response.

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

This paper uses machine learning to design cytotoxic T cell epitopes by modeling proteasomal degradation scores and testing their immunogenicity.

Focusing antibody responses to the fusion peptide in rhesusmacaques

This study uses continuous immunogen delivery in rhesus macaques to focus antibody responses on the HIV fusion peptide, identifying key residues for vaccine design.

Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity

This study shows that clonal neoantigen expression enhances dendritic cell activation and anti-tumor immunity, while subclonal expression reduces it in tumors with high intratumor heterogeneity.

Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells

This study shows vaccine boosting of CAR T-cells enhances tumor eradication by promoting antigen spreading and endogenous T-cell engagement, even in antigen-negative tumors.

Cancer tissue of origin constrains the growth and metabolism of metastases

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

Reprogramming brain immunosurveillance with engineered cytokines

This study shows engineered cytokines can reprogram brain immunosurveillance by extending their residence time in the brain using alum scaffolds, delaying tumor progression in mouse models.

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

The paper shows that spatially restricted protease activity in lymph node follicles preserves antigen integrity, leading to stronger GC responses when antigens are targeted to follicular dendritic cells.

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

This study shows that off-target antibodies from HIV trimer vaccines cause trimer disassembly, exposing more off-target epitopes and driving further off-target immune responses.

Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides

The paper identifies a D-peptide that targets murine erythrocytes and reduces anti-drug antibody responses when conjugated to therapeutic proteins.

Controlling wireframe DNA origami nuclease degradation with minor groove binders

This study demonstrates that minor groove binders can protect wireframe DNA origami from endonuclease degradation, enhancing their stability in biological environments.

The Injury Response to DNA Damage Promotes Anti-Tumor Immunity

This study shows that ex vivo DNA-damaged tumor cells as an adjuvant enhance anti-tumor immunity when combined with immune checkpoint inhibitors, requiring live injured cells and specific signaling pathways.

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

This study shows that HIV Env immunogens can be concentrated in B cell follicles using immune complexes or protein nanoparticles, enhancing their localization in lymph nodes and potentially improving immune responses.

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

This study uses DNA origami to investigate how antigen organization affects B-cell activation, finding that optimal spacing and valency enhance signaling.

DOCK2 sets the threshold for entry into the virtual memory CD8+ T cell compartment by negatively regulating tonic TCR triggering

This study shows that DOCK2 deficiency leads to increased virtual memory CD8+ T cells by enhancing TCR sensitivity to weak agonists and reducing tonic TCR triggering.

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.