Author

R. Nedellec

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:non-human primate· 2 Organism:rat· 2 Approach:statistical model· 2 Assay:structural biology· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. B. Ward· 4 shared D. R. Burton· 4 shared C. A. Cottrell· 3 shared G. Ozorowski· 3 shared L. Hangartner· 3 shared R. Andrabi· 3 shared B. Nogal· 2 shared D. J. Irvine· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersImmunology

A. B. Ward

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

M. W. Grunst, H. M. Gil, A. G. Grandea, B. J. Snow, R. Andrabi, R. Nedellec, I. Burton, N. M. Clark, S. K. Janaka, N. K. Keles, R. V. Moriarty, A. M. Weiler, S. Capuano, C. M. Fennessey, T. C. Friedrich, , D. T. Evans

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

bioRxiv · Nov 14, 2023Microbiology

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

F. Zhao, Z. T. Berndsen, N. Pedreno-Lopez, A. Burns, J. D. Allen, S. Barman, W.-H. Lee, S. Chakraborty, S. Gnanakaran, L. M. Sewall, G. Ozorowski, O. Limbo, G. Song, P. Yong, S. Callaghan, , D. Sok

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

bioRxiv · Dec 22, 2021Immunology

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

J. H. Lee, H. J. Sutton, C. A. Cottrell, I. Phung, G. Ozorowski, L. M. Sewall, R. Nedellec, C. Nakao, M. Silva, S. T. Richey, J. L. Torres, W.-H. Lee, E. Georgeson, M. Kubitz, S. Hodges, , S. Crotty

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

bioRxiv · Dec 20, 2021 · PreprintImmunology

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

B. Nogal, L. E. McCoy, M. J. van Gils, C. A. Cottrell, J. E. Voss, R. Andrabi, M. G. Pauthner, C.-H. Liang, T. Messmer, R. Nedellec, M. Shin, H. L. Turner, G. Ozorowski, R. W. Sanders, D. Burton, A. B. Ward

The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.

bioRxiv · Nov 5, 2019Immunology

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

M. G. Pauthner, J. P. Nkolola, C. Havenar-Daughton, B. Murrell, S. M. Reiss, R. Bastidas, J. Prevost, R. Nedellec, B. von Bredow, P. Abbink, C. A. Cottrell, D. W. Kulp, T. Tokatlian, B. Nogal, M. Bianchi, , D. R. Burton

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

bioRxiv · Oct 29, 2018Immunology