B.-A. Fifield

The Cyclin-Like Protein Spy1 Mediates Tumourigenic Potential of Triple Negative Breast Cancer

This study shows that knocking out Spy1 reduces proliferation, metastasis, and stemness in triple negative breast cancer cells and enhances chemotherapy response.

Atypical Cell Cycle Regulation Promotes Mammary Stem Cell Expansion and Therapeutic Resistance

This study shows Spy1 promotes mammary stem cell expansion and therapy resistance by overriding cell cycle checkpoints, especially in combination with p53 loss, leading to more aggressive breast cancers.

The ALDH1A3 Reporter Construct: A Novel Mechanism of Identifying and Tracking the Breast Cancer Stem Cell Population

The paper develops an ALDH1A3 reporter construct to identify and track breast cancer stem cells, enhancing the ability to study their dynamics and role in pathogenesis.

THE STABILIZATAION OF C-MYC BY THE NOVEL CELL CYCLE REGULATOR, SPY1, DECREASES EFFICACY OF BREAST CANCER TREATMENTS

This study shows that Spy1 stabilizes c-Myc, reducing breast cancer treatment efficacy, and that targeting Spy1 can enhance chemotherapy response in TNBC.

The Atypical Cyclin-Like Protein Spy1 Overrides p53-Mediated Tumour Suppression and Promotes Susceptibility to Breast Tumorigenesis

This study shows Spy1 promotes breast tumorigenesis by evading p53-mediated tumor suppression and enhancing mammary epithelial proliferation.