THE STABILIZATAION OF C-MYC BY THE NOVEL CELL CYCLE REGULATOR, SPY1, DECREASES EFFICACY OF BREAST CANCER TREATMENTS
R.-M. Ferraiuolo, B.-A. Fifield, C. Hamm, L. A. Porter
This study shows that Spy1 stabilizes c-Myc, reducing breast cancer treatment efficacy, and that targeting Spy1 can enhance chemotherapy response in TNBC.
bioRxiv · Mar 11, 2022 · PreprintCancer Biology