Pannexin 1 modulates angiogenic activities of human endothelial colony-forming cells through IGF-1 mechanism and is a marker of senescence
H.-I. Yeh, T.-Y. Tien, Y.-J. Wu, C.-H. Su, C.-L. Hsieh, B.-J. Wang, Y.-N. Lee, Y. Su
This study shows that reducing Panx1 in senescent endothelial colony-forming cells increases IGF-1 production, improving angiogenic activity and limb perfusion in mice.
bioRxiv · May 1, 2023Cell Biology