Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer
M. K. Jolly, B.-T. Preca, S. C. Tripathi, D. Jia, S. M. Hanash, T. Brabletz, M. P. Stemmler, J. Maurer, H. Levine
The paper identifies interconnected feedback loops among ESRP1, HAS2, and CD44 that regulate ZEB1 levels and drive epithelial-hybrid-mesenchymal transition in cancer, with ESRP1 as a key regulatory node.
bioRxiv · Feb 5, 2018Cancer Biology