S. C. Tripathi

Huntingtin Interacting Protein-1 expression is regulated via HIF2 axis in Lung Adenocarcinoma

The paper investigates HIP1 expression regulation via the HIF2 axis in lung adenocarcinoma, showing its role in tumor suppression and metabolic changes.

NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial/mesenchymal phenotype

This study identifies NFATc as a non-canonical phenotypic stability factor that stabilizes hybrid epithelial/mesenchymal phenotypes by enabling coexistence and transitions between epithelial, mesenchymal, and hybrid states.

NRF2 activates a partial Epithelial-Mesenchymal Transition and is maximally present in a hybrid Epithelial/Mesenchymal phenotype

This study shows NRF2 stabilizes a hybrid epithelial/mesenchymal phenotype by upregulating both E-cadherin and ZEB, and correlates this phenotype with poor survival in cancer.

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

The paper identifies interconnected feedback loops among ESRP1, HAS2, and CD44 that regulate ZEB1 levels and drive epithelial-hybrid-mesenchymal transition in cancer, with ESRP1 as a key regulatory node.

Numb prevents a complete EMT by modulating Notch signalling

This study shows Numb stabilizes a hybrid E/M phenotype by inhibiting Notch-driven full EMT, correlates with poor cancer survival, and predicts its role in tumor-initiation.

Epithelial-mesenchymal plasticity: How have quantitative mathematicalmodels helped improve our understanding?

This paper reviews how quantitative mathematical models have advanced understanding of epithelial-mesenchymal plasticity in tumors by explaining data, guiding experiments, and improving conceptual frameworks.

Distinguishing Mechanisms Underlying EMT Tristability

The paper uses experimental and theoretical approaches to evaluate two models of EMT dynamics, finding experimental evidence supporting the ternary chimera switch model over the cascading bistable switches model.