Author

S. M. Hanash

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Levine· 3 shared M. K. Jolly· 3 shared S. C. Tripathi· 3 shared D. Jia· 2 shared H. Katayama· 2 shared A. Adel Fouad Abdelhakeem· 1 shared A. Huang· 1 shared A. J. Lazar· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCancer Biology

H. Levine

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6 papers

Recent·Most cited

EGFR inhibition in lung adenocarcinoma upregulates cell surface expression of the placental antigen ALPP and enhances efficacy of ALPP-ADC therapy

y. chen, M. J. Hong, H. Xu, J. Vykoukal, S. Park, y. Cai, R. A. Leon-Letelier, E. Irajizad, F. C. Hsiao, J. B. Dennison, E. J. Ostrin, J. F. Fahrmann, H. Katayama, S. M. Hanash

The paper shows EGFR inhibition increases ALPP surface expression in lung adenocarcinoma, enhancing the effectiveness of ALPP-ADC therapy.

bioRxiv · Mar 27, 2023 · PreprintCancer Biology

P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis

M. Zhu, R. Peng, X. Liang, Z. Lan, M. Tang, P. Hou, J. H. Song, C. S. L. Mak, J. Park, S.-e. Zheng, A. Huang, X. Ma, R. Chen, Q. Chang, C. J. Logothetis, , G. Wang

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

bioRxiv · Jan 24, 2021Cancer Biology

Cell-of-Origin Analysis of Metastatic Gastric Cancer Uncovers the Origin of Inherent Intratumor Heterogeneity and a Fundamental Prognostic Signature

R. Wang, S. Song, K. Harada, G. Han, M. P. Pizzi, M. Zhao, G. Tatlonghari, S. Zhang, Y. Wang, S. Zhao, B. Badgwell, M. B. Murphy, N. Shanbhag, J. Estrella, S. Roy-Chowdhuri, , L. Wang

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

bioRxiv · Aug 5, 2019 · PreprintCancer Biology

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

M. K. Jolly, B.-T. Preca, S. C. Tripathi, D. Jia, S. M. Hanash, T. Brabletz, M. P. Stemmler, J. Maurer, H. Levine

The paper identifies interconnected feedback loops among ESRP1, HAS2, and CD44 that regulate ZEB1 levels and drive epithelial-hybrid-mesenchymal transition in cancer, with ESRP1 as a key regulatory node.

bioRxiv · Feb 5, 2018Cancer Biology

Epithelial-mesenchymal plasticity: How have quantitative mathematicalmodels helped improve our understanding?

M. K. Jolly, S. C. Tripathi, J. A. Somarelli, S. M. Hanash, H. Levine

This paper reviews how quantitative mathematical models have advanced understanding of epithelial-mesenchymal plasticity in tumors by explaining data, guiding experiments, and improving conceptual frameworks.

bioRxiv · Mar 29, 2017Cancer Biology

Distinguishing Mechanisms Underlying EMT Tristability

D. Jia, M. K. Jolly, S. C. Tripathi, P. D. Hollander, B. Huang, M. Lu, M. Celiktas, E. Ramirez-Pena, E. Ben-Jacob, J. N. Onuchic, S. M. Hanash, S. A. Mani, H. Levine

The paper uses experimental and theoretical approaches to evaluate two models of EMT dynamics, finding experimental evidence supporting the ternary chimera switch model over the cascading bistable switches model.

bioRxiv · Jan 6, 2017Cancer Biology