Cell-specific cargo delivery using synthetic bacterial spores
Minsuk Kong, Domenico D’Atri, Maria Teresa Bilotta, Bailey Johnson, Taylor B. Updegrove, Devorah L. Gallardo, Federico Machinandiarena, I-Lin Wu, Maira A. Constantino, Stephen M. Hewitt, Kandice Tanner, David J. FitzGerald, Kumaran S. Ramamurthi
This study demonstrates that SSHELs, synthetic bacterial spore-like particles, can deliver chemotherapy to HER2-positive cancer cells with reduced toxicity and effectiveness in tumor models.
Cell Reports · Jan 1, 2023Peer-reviewedSynthetic Biology