Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids
Baiyu Zhu, Lakshmi Swarna Mukhi Pidugu, Mary E. Cook, Xinyu Nie, E. A. P. Tharaka Amarasekara, Jérôme S. Menet, Alexander C. Drohat, Jonathan T. Sczepanski
This study shows that TDG binds R-loops and removes 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids, supporting a role for R-loops in DNA demethylation.
Journal of Biological Chemistry · Feb 26, 2026Peer-reviewedBiochemistry