Jonathan T. Sczepanski

Glycine detection with a nuclease-stable L-RNA sensor

This paper develops a nuclease-stable L-RNA glycine sensor using cross-chiral ligation, enabling extracellular glycine detection in serum.

Metallothionein loss in cancer cells contributes to increased mutations through defective DNA repair and metabolic imbalance

This study shows that loss of metallothionein (MT) in cancer cells increases mutations by impairing DNA repair and causing metabolic imbalance.

Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids

This study shows that TDG binds R-loops and removes 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids, supporting a role for R-loops in DNA demethylation.

An Expanded Substrate Scope for Cross-Chiral Ligation Enables Efficient Synthesis of Long L-RNAs

This paper introduces a method to synthesize long L-RNAs using cross-chiral ligase ribozymes and chemical activation, enabling efficient assembly of long sequences.