Jérôme S. Menet

Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids

This study shows that TDG binds R-loops and removes 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids, supporting a role for R-loops in DNA demethylation.

Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse Liver

This study uses single-nucleus multiomics to analyze circadian rhythms in mouse liver, revealing gene expression and chromatin accessibility patterns across the day.

Regulation of stereotypic chromatin conformations at enhancers by CLOCK:BMAL1

The paper uses single molecule footprinting to study how CLOCK:BMAL1 regulates chromatin conformations at enhancers, revealing cooperative binding and nucleosome remodeling.

The Role of Terminal Uridyl Transferases in the Circadian Rhythm

This study shows that terminal uridylation of mRNA is rhythmic in mouse liver and that knocking down TUT4 and TUT7 disrupts circadian rhythms.

Lack of food intake during shift work alters the heart transcriptome and leads to cardiac fibrosis and inflammation in rats

This study shows that shift work in rats alters heart gene expression, leading to fibrosis and inflammation when food is restricted during work hours, but not when food is available.

Isoform-specific regulation of rhythmic gene expression by alternative polyadenylation

The paper shows that rhythmic gene expression in mouse liver is largely regulated by isoform-specific alternative polyadenylation, with rhythmic APA isoforms generating 24-hour rhythms in 3' UTR length.

Tissue-specific BMAL1 cistromes reveal that enhancer-enhancer interactions regulate rhythmic transcription

The paper shows BMAL1 DNA binding is tissue-specific and regulates rhythmic transcription through enhancer-enhancer interactions in the mouse liver.