Cytotoxic Vδ2+T cell subsets expand in response to malaria in human tonsil and spleen organoids
Kathleen D. Press, Florian A. Bach, Elsa Solà, Kylie Camanag, Nicholas L. Dooley, Anselma Ivanawati, Damian A. Oyong, Mayimuna Nalubega, Abel Kakuru, Sedrack Matsiko, Nankya Felistas Namirimu, Kenneth Musinguzi, Annet Nalwoga, Evelyn Nansubuga, John Ategeka, , Prasanna Jagannathan
This study shows that malaria exposure increases cytotoxic Vδ2+ T cell expansion in human tonsil and spleen organoids, with clonal expansion and activation, while not significantly affecting influenza vaccine responses.
PLoS Pathogens · Apr 10, 2026Peer-reviewedImmunology