Florian A. Bach

Maternal microchimerism in Malian cord blood is associated with fewer Pf-responsive ZBTB16+ CD4 and Vγ9Vδ2 T cells, and with infant malaria outcomes.

The paper examines how exposure to P. falciparum and common cold viruses influences vaccine responses in Ugandan infants, finding positive associations between microbial exposure and antibody levels.

The paper identifies CXCR6⁺ CD127⁻ Tr1 cells as key regulators in Plasmodium falciparum infection, showing they balance immunity and parasite persistence.

This study shows that malaria exposure increases cytotoxic Vδ2+ T cell expansion in human tonsil and spleen organoids, with clonal expansion and activation, while not significantly affecting influenza vaccine responses.

The paper examines how maternal malaria and early-life infections affect P. falciparum-specific antibody responses in infants, finding no protective association between maternal antibodies or early infections and clinical malaria.