Chloe M. Kashiwagi

Cytotoxic Vδ2+T cell subsets expand in response to malaria in human tonsil and spleen organoids

This study shows that malaria exposure increases cytotoxic Vδ2+ T cell expansion in human tonsil and spleen organoids, with clonal expansion and activation, while not significantly affecting influenza vaccine responses.

Prenatal Arsenic Exposure and Gene Expression in Fetal Liver, Heart, Lung, and Placenta

This study examines gene expression changes in fetal liver, heart, lung, and placenta after prenatal arsenic exposure in mice, identifying immune-related pathway alterations and reduced Gbp3 expression in female placentas.

Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging

This study identifies age-related lipidomic changes in neural stem cells using mass spectrometry and shows that lipid modifications affect NSC function and activation.

In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain

The paper uses CRISPR-Cas9 screens in vitro and in vivo to identify gene knockouts that enhance neural stem cell activation in aged mice, finding that GLUT4 knockout is a top rejuvenating intervention.