Perturbed functional networks in Alzheimers Disease reveal opposing roles for TGIF and EGR3
Saranya Canchi, Balaji Raao, Deborah Masliah, Sara Brin Rosenthal, Roman Šášik, Kathleen M Fisch, Philip L. De Jager, David A. Bennett, Robert A. Rissman
The paper identifies TGIF1 and EGR3 as master regulators in Alzheimer's Disease by integrating gene expression and protein interactions, revealing their opposing roles in neuroprotection and synaptic deficits.
bioRxiv · Mar 22, 2018 · PreprintBioinformatics