Kathleen M Fisch

This study identifies functional differences in term decidual natural killer cells compared to early gestation and develops a protocol to generate functional early gestation-like dNK from iPSC.

The paper identifies widespread RNA editing changes in pediatric ALL, linking them to clinical outcomes and potential therapeutic targets.

This study identifies VGLL1 as a key regulator of trophoblast development by integrating BMP, WNT, and HIPPO signaling through chromatin remodeling and transcriptional control in human stem cells.

This study shows FAK inhibition in ovarian tumors increases macrophage CXCL13 production via omega-3 fatty acids, enhancing B cell infiltration and immunotherapy response.

The paper uses single-cell RNA sequencing to compare transcriptional differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells in early human placenta.

The paper profiles retinal nuclei from Alzheimer's Disease and non-diagnosed cases to identify AD-associated gene expression changes in retinal microglia.

The paper investigates how age affects the expression of PRR genes and ACE2 in human dermal fibroblasts, linking increased expression to higher risk of severe COVID-19 outcomes.

The paper describes a standardized RNA-Seq pipeline for spaceflight data, enabling reproducible analysis of gene expression changes in astronauts and organisms exposed to spaceflight.

The paper presents a large-scale cancer pharmacogenomic screen with 11,576 experiments on 910 drug combinations across 85 cancer cell lines, enabling crowd-sourced prediction of synergistic drug pairs and biomarkers.

The paper identifies TGIF1 and EGR3 as master regulators in Alzheimer's Disease by integrating gene expression and protein interactions, revealing their opposing roles in neuroprotection and synaptic deficits.