Author

Sara Brin Rosenthal

University of California San DiegoORCID 0000-0002-9072-8032Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Kathleen M FischiD· 3 shared Robert A. RissmaniD· 2 shared Roman ŠášikiD· 2 shared Adam MarkiD· 1 shared Allen WangiD· 1 shared Andrey A. BobkoviD· 1 shared Balaji Raao· 1 shared Branko StefanoviciD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

Kathleen M FischORCID

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Author profile →

4 papers

Recent·Most cited

Widespread remodeling of the RNA editome underlies transcriptional and clinical heterogeneity in pediatric acute lymphoblastic leukemia

Sara Brin Rosenthal, Thomas C. Whisenant, Roman Šášik, Maria Rivera, Geena Il Defonso, Charles-Alexandre Roy, Sabina Enlund, Rawan Shraim, Kathleen M Fisch, David T. Teachey, Frida Holm, Dennis John Kuo, Qingfei Jiang

The paper identifies widespread RNA editing changes in pediatric ALL, linking them to clinical outcomes and potential therapeutic targets.

bioRxiv · Dec 6, 2025 · PreprintCancer Biology

LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis

Hyun Young Kim, Orel Mizrahi, Wonseok Lee, Sara Brin Rosenthal, Cuijuan Han, Brian A. Yee, Steven M. Blue, Jesiel Diaz, Jyotiprakash Jonnalagadda, Kanani Hokutan, Haeum Jang, Chen-Ting Ma, Andrey A. Bobkov, Eduard A. Sergienko, Michael R. C. Jackson, , David A. Brenner

This study shows LARP6 regulates fibrogenic gene translation in liver fibrosis by interacting with collagen mRNAs and reducing fibrosis in human HSCs.

bioRxiv · Jan 16, 2025 · PreprintCell Biology

Cell-associated Transcriptional Alterations in the Retinal of Alzheimer's Disease

Jennifer Ngolab, Adam Mark, Justin Buchanan, Shaina Korouri, Sebastian Priessl, Sara Brin Rosenthal, Allen Wang, Kathleen M Fisch, Robert A. Rissman

The paper profiles retinal nuclei from Alzheimer's Disease and non-diagnosed cases to identify AD-associated gene expression changes in retinal microglia.

bioRxiv · Aug 18, 2022 · PreprintNeuroscience

Perturbed functional networks in Alzheimers Disease reveal opposing roles for TGIF and EGR3

Saranya Canchi, Balaji Raao, Deborah Masliah, Sara Brin Rosenthal, Roman Šášik, Kathleen M Fisch, Philip L. De Jager, David A. Bennett, Robert A. Rissman

The paper identifies TGIF1 and EGR3 as master regulators in Alzheimer's Disease by integrating gene expression and protein interactions, revealing their opposing roles in neuroprotection and synaptic deficits.

bioRxiv · Mar 22, 2018 · PreprintBioinformatics