MTSS1/Src family kinase Dysregulation Underlies Multiple Inherited Ataxias
Alexander S. Brown, Pratap Meera, Banu Altindag, Ravi Chopra, Emma Perkins, Sharan Paul, Daniel R. Scoles, Eric Tarapore, Jessica Magri, Haoran Huang, M. T. Jackson, Vikram G. Shakkottai, Thomas S. Otis, Stefan M. Pulst, Scott X. Atwood, Anthony E. Oro
This study identifies MTSS1/Src family kinase dysregulation as a common mechanism in multiple inherited ataxias and shows SFK inhibitors can delay disease progression in mouse models.
Proceedings of the National Academy of Sciences · Dec 7, 2018Peer-reviewedNeuroscience