Haoran Huang

This study re-examines the role of DR6 in Wallerian degeneration and finds no effect on axon degeneration or Schwann cell injury responses, contradicting prior reports.

This study identifies ER stress and HSP90-dependent UPR as mechanisms underlying delayed onset of SCA6 motor dysfunction and Purkinje cell spiking abnormalities.

This study identifies increased intrinsic membrane excitability in SCA1-KI mice as a novel mechanism underlying hypertrophic olivary degeneration without inhibitory denervation.

This study shows that neuronal activity regulates MATR3 levels and function through calpain cleavage and Ca2+/calmodulin binding, linking these processes to ALS pathology.

The paper identifies optimal chlorzoxazone-baclofen concentrations to improve cerebellar dysfunction in SCA1 without toxicity, proposing a dose escalation trial design.

This study identifies MTSS1/Src family kinase dysregulation as a common mechanism in multiple inherited ataxias and shows SFK inhibitors can delay disease progression in mouse models.