A transcriptional atlas of the pubertal human growth plate reveals direct stimulation of cartilage stem cells by growth hormone.
Nelson Tsz Long Chu, Ostap A. Dregval, Farasat Zaman, Lei Li, Xin Tian, Xin Liu, Dana Trompet, Baoyi Zhou, Jussi Heinonen, Claes Ohlsson, Lars S Savendahl, Igor I. Adameyko, Andrei S. Chagin
This study reveals GH directly stimulates human growth plate stem cell proliferation via TGF{beta} and ERK pathways, offering insights into growth mechanisms and treatment optimization.
Science Translational Medicine · Apr 15, 2026Peer-reviewedCell Biology